P014-E001 Moderate
The difference-in-means estimator is unbiased for the probability-weighted average direct effect, in which , and not in general for the target printed on p. 131, which weights the assignment vectors in equally.
Section 2, p. 131 (PDF p. 4): the first display, which defines ; the display that defines ; and the display for with the sentence “where the result trivially follows from linearity of expectations”. The corresponding claim is in the Introduction, p. 129 (PDF p. 2)
See also under Formal statements (Lean): P014-T1, P014-T2, P014-T3, P014-T4, P014-T7, P014-T9, P014-T10
As printed
Denote the individual average potential outcome under treatment for all subjects ,
…
Then our primary target is the average direct effect (Hudgens and Halloran, 2008) of treatment for subjects who are close to the threshold:
…
Formally, the difference-in-means estimator for subjects local to the threshold,
Then, under the assumption of local randomization, the difference-in-means estimator as applied to subjects local to the threshold is unbiased for the average direct effect for subjects near the threshold:
where the result trivially follows from linearity of expectations.
The problem
The first display defines as an average of over the distinct assignment vectors in whose th component is . Each such vector counts once, whatever its probability. The expectation of the difference-in-means estimator weights each assignment vector by its probability. Under local randomization, by linearity of expectation, I have
This equals the printed target for all potential outcomes only if, for each subject in the window and each , the conditional distribution of given is uniform on its support. Local randomization does not imply this. Under it the arrangements of the running variable in the window are equiprobable, so that the subjects in the window have equal probabilities of treatment. However, the allocation outside the window is “left completely unspecified”, and the number of arrangements that produce a particular assignment vector of the whole population can vary from one vector to another. The distinct assignment vectors can then have unequal probabilities, so the identity need not hold for the printed and cannot be justified by linearity of expectations alone.
The prose around the displays describes the probability-weighted quantity: the target is “the average outcome we would expect to see in treated subjects (across all subjects within the window and across all randomizations)” minus the same for control subjects. The display can disagree with the prose when assignment vectors have unequal probabilities, and the text does not settle whether the probabilities were omitted from the display or an assumption of uniform assignment was intended. To keep the allocation outside the window unrestricted, the correction inserts in both sums of the first display. The estimator is unchanged and the estimand changes.
Evidence an exact counterexample
The evidence is two exact counterexamples to the printed identity, and a derivation of the corrected one.
The first example. Let , and . Let be a uniformly random arrangement of the values , and , and set if and otherwise. The vector has six support points, each of probability . Subjects 1, 2 and 3 are always in the window and subject 4 never is, the values in the window are distinct and the same in every case, and exactly one subject in the window is treated. Every condition printed on p. 130 holds, with the no-ties condition read for distinct subjects (P014-E003), and in addition all six arrangements are equiprobable. Each subject in the window is treated with probability . For all sixteen assignment vectors , set and .
| Arrangements | ||||
|---|---|---|---|---|
| 1 | 0 | 0 | ||
| 1 | 1 | 0 | ||
| 2 | 0 | 0 | ||
| 2 | 0 | 0 |
The three subjects in the window always have the same outcome, so that for every assignment and . The printed counts each row of the table once. For subject 1 under control, the rows with are the first three, with outcomes , and , and the printed average is . Given , these rows have probabilities , and , and the conditional expectation is .
| Subject | Printed | Printed | ||
|---|---|---|---|---|
| 1 | 0 | 0 | ||
| 2 | 0 | 0 | ||
| 3 | 0 | 0 |
From the second and third columns, I obtain the printed target, and from the last two the probability-weighted target:
The printed identity fails by .
The second example. Let , and . Let be a uniformly random arrangement of , and , so that two subjects in the window are treated, and set if and otherwise. Set and all other potential outcomes equal to zero. The same conditions hold. The assignment vectors and have probability each, and and have probability each. The estimator equals at and elsewhere, so that . The printed is , and I find . The conditional expectation is , and the probability-weighted target is .
| Example | Printed | Probability-weighted target | |
|---|---|---|---|
| First | 0 | 0 | |
| Second | 1 | 1 |
The corrected identity. Let be the set of subjects in the window and . Suppose that with probability one, where , and that for every . Both hold when the distinct values in the window, of which are nonnegative, are arranged uniformly at random: a subject receives each value in of the arrangements. I write and
Since the numbers of treated and control subjects in the window are fixed, I may write
For each , by the definition of and the identity , I have
Substituting these into the expectation of the previous display, I obtain
Note that this derivation uses no assumption on the allocation outside the window. In both examples the difference between and the probability-weighted target vanishes identically as a linear form in the 48 potential outcomes of the three subjects in the window, and the difference between and the printed target does not.
When the printed target is correct. If is uniform on , then the two definitions of agree. This is the case when the assignments outside the window are fixed, since each assignment vector is then produced by exactly arrangements. With fixed in either example, the printed identity holds for all potential outcomes. The two definitions also agree when there is no interference, since then depends on alone.
What survives
The difference-in-means estimator, the potential-outcome model with arbitrary interference and the local randomization design are unchanged. The estimator is exactly unbiased for the probability-weighted target with no restriction on the allocation outside the window. This implies that the statement of the Introduction, that it is unbiased for a regime-specific causal effect, holds for that target. The printed target and identity hold as printed when is uniform on its support, and when there is no interference. The definition of the estimand changes; in the first example its value changes from to . The paper reports no simulations, application or numerical results that depend on the definition. The paragraph on inference on pp. 131–132 refers to the same target, and its sufficient conditions were not examined for this correction.
Corrected
Let be the fixed set of subjects in the window and . Assume local randomization: the distinct, fixed values of the running variable in the window, of which are nonnegative with , are arranged among the subjects in uniformly at random, so that with probability one and for every . The allocation outside the window is not restricted. The potential outcomes are fixed and may depend on the whole assignment vector. Denote the individual average potential outcome under treatment for all subjects ,
Then our primary target is the average direct effect (Hudgens and Halloran, 2008) of treatment for subjects who are close to the threshold:
The difference-in-means estimator is as printed. Then, under the assumption of local randomization, the difference-in-means estimator as applied to subjects local to the threshold is unbiased for the average direct effect for subjects near the threshold:
where the result follows from the fixed numbers of treated and control subjects in the window, their common probability of treatment, and linearity of expectations. The brackets in the display for are those of P014-N004. The treated-minus-control contrast uses the reverse of Hudgens and Halloran’s sign convention (P014-N002).
Alternatively, the definition of printed on p. 131 can be kept under the additional assumption that is uniformly distributed on , which holds, for instance, when the assignments of the subjects outside the window are fixed. The two definitions then agree.



![Four entries of the reference list: Lee (2008), Liu and Hudgens (2014), Neyman (1923) and Rosenbaum (2007). A red box marks the closing quotation mark after 'elections.' in the Lee entry. Two red boxes mark the third and fourth lines of the Neyman entry, which read 'erzy Splawa, D. M. Dabrowska, and T. P. Speed [1923.] 1990. On the application of probability theory to agricultural experiments: Essay on principles, section 9.' A red box marks the words 'American American' in the journal name of the Rosenbaum entry.](exhibits/P014-E004-b.png)





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